Research Scientist I - Downstream Processing/ Raziskovalec I

Job Description:

Salary Range:EUR20,300.00 - EUR37,700.00

Job Description SummaryLocation: Menges, Slovenia LI#onsite

Role Purpose:
Our R&D unit in Mengeš is looking for a motivated scientist in field of Downstream Processing (DSP) to join us and help us develop a diverse portfolio of biotherapeutic modalities.

As a Research Scientist you must demonstrate good understanding of technologies in recombinant protein production and purification to evaluate the developability of various biologics modalities covered by Novartis Biomedical Research and Development units.
We offer a stimulating work environment, ample opportunities for growth and development, and the chance to make a significant impact on the future of medicine. If you are a motivated and talented scientist with a passion for biomedical research, we invite you to apply and become a part of our dynamic team at Novartis.

Naša R&D enota v Mengšu išče motiviranega raziskovalca s področja procesov izolacij biloških učinkovin (DSP), ki se nam bo pridružil in nam pomagal razvijati raznolik portfelj bioterapevtikov.

Kot raziskovalec morate izkazovati dobro razumevanje tehnologij za proizvodnjo in čiščenje rekombinantnih proteinov, da boste lahko ocenili razvojni potencial različnih bioloških terapevtskih kandidatov, ki jih pokrivajo enote Novartis Biomedicinske raziskave in Razvoj.

Nudimo spodbudno delovno okolje, številne priložnosti za rast in razvoj ter možnost pomembnega vpliva na prihodnost medicine. Če ste motiviran in nadarjen znanstvenik s strastjo do biomedicinskih raziskav, vas vabimo, da se prijavite in postanete del naše dinamične ekipe v Novartisu.

Job Description
Key responsibilities:
* Downstream purification of recombinantly expressed proteins from suspension CHO culture from small to large scale (up to 200L)
* Executing Aekta liquid chromatography, filtration, and centrifugation technologies for the purification of recombinant monoclonal antibodies, multispecific antibodies and other therapeutic proteins
* Executing experimental steps and lab techniques according to laboratory protocols with input from senior lab members
* Actively participating in lab organization, including maintaining equipment and preparing devices for purifications
* Accurately and timely process samples, prepare shipments, contribute to result interpretation, participate in lab meetings, prepare summary presentations and timely document all data in electronic lab journal and databases 
* Execute USP supporting activities including expanding and mainaining CHO cells in suspension cultures from small to large scale (up to 200 L)

Minimum Requirements - What you will bring to the role:
* MSc University degree in biochemistry, chemistry, chemical technology or other relevant discipline; or BSc University degree in biochemistry, chemistry, chemical technology or other relevant discipline with at least 2 year of relevant work experience
* Good theoretical and strong practical laboratory experience in recombinant protein purification, liquid chromatography, filtration
* High learning ability to acquire expertise in new technologies and technical equipment
* Excellent organizational skills with the ability to run multiple projects in parallel
* Reliable and flexible team player, accustomed to sharing tasks and projects
* Fluency in English (oral/written);

Desirable skills:
* Experience in a neighboring discipline (Upstream Processing)

Benefits & Rewards

At Novartis, we're committed to reimagining medicine together - and rewarding the people who make it happen.

Expected Annual Base Salary Range for role: EUR20,300 to EUR37,700

The base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.

In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters.

The rewards of being part of our team go far beyond base pay and incentives. We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. In addition, we provide flexible and hybrid working options, where possible, and minimum 14 weeks paid parental leave.

Ključne odgovornosti

* Izolacija rekombinantno izraženih proteinov iz suspenzijskih kultur CHO od majhnega do velikega merila (do 200 L)

* Izvajanje tekočinske kromatografije ÄKTA, filtracije in centrifugiranja za čiščenje rekombinantnih monoklonskih protiteles, multispecifičnih protiteles in drugih terapevtskih proteinov

* Izvajanje eksperimentalnih korakov in laboratorijskih tehnik v skladu z laboratorijskimi protokoli ob podpori izkušenih članov laboratorija

* Aktivno sodelovanje pri organizaciji laboratorija, vključno z vzdrževanjem opreme in pripravo naprav za izolacije

* Natančna in pravočasna obdelava vzorcev, priprava pošiljk, prispevanje k interpretaciji rezultatov, sodelovanje na laboratorijskih sestankih, priprava povzetkov predstavitev ter pravočasno dokumentiranje vseh podatkov v elektronskem laboratorijskem dnevniku in podatkovnih bazah

* Izvajanje podpornih aktivnosti USP, vključno z razširjanjem in vzdrževanjem celic CHO v suspenzijskih kulturah od majhnega do velikega merila (do 200 L)

Minimalne zahteve - kaj boste prinesli v vlogo:

* Univerzitetna izobrazba / magisterij (MSc) s področja biokemije, kemije, kemijske tehnologije ali druge ustrezne discipline; ali Visokošolska izobrazba (BSc) s področja biokemije, kemije, kemijske tehnologije ali druge ustrezne discipline z najmanj 1 letom ustreznih delovnih izkušenj

* Dobro teoretično in močno praktično laboratorijsko znanje s področja čiščenja rekombinantnih proteinov, tekočinske kromatografije in filtracije

* Visoka sposobnost učenja za pridobivanje strokovnega znanja o novih tehnologijah in tehnični opremi

* Odlične organizacijske sposobnosti z zmožnostjo hkratnega dela na več projektih

* Zanesljiv in prilagodljiv timski sodelavec, vajen deljenja nalog in projektov

* Tekoče znanje angleščine (ustno/pisno);

Zaželena znanja in izkušnje:

* Izkušnje s sorodnega področja (Upstream Processing)

Koristi in nagrade
V Novartisu smo zavezani skupnemu preoblikovanju medicine - in nagrajevanju ljudi, ki jo uresničijo. Pričakovani letni osnovni plačni razpon za delovno mesto: EUR20,300 do EUR37,700
Osnovna plača je določena glede na spolno nevtralne cilje, kot so relevantne veščine, kompetence in izkušnje v skladu s politiko plač Novartisa, ob vstopu v Novartis pa se redno pregleduje.
Poleg osnovne plače ste morda upravičeni do bonusa na podlagi uspešnosti, odvisno od določenih parametrov uspešnosti. Nagrade, ki jih prinaša članstvo v naši ekipi, segajo daleč preko osnovne plače in spodbud. Ponujamo tudi različne konkurenčne ugodnosti v naravi, ki vam pomagajo uspevati osebno in poklicno, kot so zavarovalni načrti, pokojninski načrti, viri za dobro počutje in globalni programi priznanja. Poleg tega ponujamo prilagodljive in hibridne možnosti dela, kjer je mogoče, ter najmanj 14 tednov plačanega starševskega dopusta.

Skills Desired