DMPK Modeller (Contrato Temporal)

Beschreibung:

Position Summary

You will join a DMPK drug discovery team in Spain to influence how we translate science into safer, more effective medicines. You will design and deliver modelling and simulation strategies to support discovery and early development projects. You will work closely with project teams across disciplines and locations to inform dose decisions, drug-drug interaction risk, and human pharmacokinetics. We value collaborative thinkers who communicate clearly, mentor others, and apply modelling with scientific rigour and practical judgement. This role is part of GSK's Global Health Medicines R&D team which aims to positively impact infectious diseases such as Malaria, Tuberculosis, and AMR that disproportionally impact lower income countries.

Responsibilities
This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

* Lead development and application of pharmacokinetic and pharmacokinetic-pharmacodynamic (PK/PD) models for small molecules and other modalities to inform project decisions.
* Design and deliver translational modelling strategies, including dose prediction and human exposure projections.
* Assess and quantify drug-drug interaction (DDI) risk using in vitro-in vivo translation and modelling approaches.
* Communicate model assumptions, results and uncertainty clearly to cross-functional teams and governance bodies.
* Mentor and coach colleagues on modelling methods, good practices and scientific interpretation.
* Contribute to regulatory and internal documents with clear, evidence-based modelling narratives.

Qualifications/Skills

Basic Qualifications:
* Degree in Pharmacology, Pharmaceutics, Pharmacokinetics, Mathematics, Bioengineering, or a related discipline.
* Practical experience in population PK, PBPK, or mechanistic PK/PD modelling in a biopharma setting.
* Hands-on experience with modelling software such as, Matlab (symbiology), Monolix, Simcyp, GastroPlus, or equivalent.
* Experience translating in vitro and preclinical data to humans.
* Strong written and verbal communication skills in English; ability to explain modelling outcomes to non-specialists.
* Experience working in cross-functional project teams.

Preferred Qualifications:
If you have the following characteristics, it would be a plus:

* PhD in a relevant field or equivalent industry experience.
* Experience with drug-drug interaction modelling and enzyme/transporter mechanistic frameworks.
* Familiarity with multiple modalities beyond small molecules.
* Experience preparing modelling sections for regulatory documents and interacting with regulators.
* Programming skills in R, MATLAB, or Python for data analysis and model development.
* Experience in infectious disease drug discovery.
* Track record of mentoring and developing junior scientists.

Work Location:

This role is based in the Tres Cantos, Spain and offers a hybrid working model, combining on-site and remote work.

Spanish Salary Range / Rango salarial en España: EUR 60,525 to EUR 100,875 The annual gross base salary range for new hires in this position is listed above for each applicable location. These ranges take into account a number of factors including the candidate's skills, experience, education level and the market rate for the role. In addition, this position may offer an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. More detailed information on the total benefits package will be supplied during the recruitment process. This role is available for applicants from multiple locations, and therefore salary ranges for certain locations are also shown. Salary ranges for other locations are shown because some markets have pay transparency laws that require salary information on job postings, and those locations are potential job sites for this role. If salary ranges are not displayed in the job posting for a specific location or country, the relevant compensation will be discussed during the recruitment process. Please note salaries vary by country based on the candidate's skills, experience, education level and the market rate for the role. Offers are typically made within the advertised range based on the candidate's skills, experience and qualifications, with the upper end generally reserved for highly experienced candidates or other exceptional circumstances aligned with these criteria. El rango salarial bruto anual para nuevos empleados en esta posición se encuentra se indica más arriba para cada ubicación correspondiente. Estos rangos tienen en cuenta varios factores, como las habilidades, la experiencia, el nivel educativo de la persona candidata y las condiciones del mercado para el puesto. Además, esta posición puede incluir un bonus anual y la posibilidad de participar en nuestro programa de incentivos a largo plazo basado en acciones, en función del nivel del puesto. Durante el proceso de selección se facilitará información más detallada sobre el paquete completo de beneficios. Además, esta posición puede incluir un bonus anual y la posibilidad de participar en nuestro programa de incentivos a largo plazo basado en acciones, en función del nivel del puesto. Durante el proceso de selección se facilitará información más detallada sobre el paquete completo de beneficios. Este puesto está abierto a candidatos en distintas ubicaciones por lo que también se muestran los rangos salariales correspondientes a algunas de ellas. En determinados mercados, la legislación sobre transparencia salarial exige incluir información retributiva en las ofertas de empleo, y esas ubicaciones se contemplan como posibles destinos para este puesto. Si en una ubicación o país concreto no se indica un rango salarial en la oferta, la compensación se tratará durante el proceso de selección. Por favor, tenga en cuenta que los salarios varían según el país en función de las habilidades, experiencia, nivel educativo del candidato y las condiciones del mercado para el puesto. Las ofertas suelen situarse dentro del rango anunciado atendiendo a las habilidades, experiencia y cualificaciones del candidato, reservándose habitualmente el tramo superior para candidatos altamente experimentados u otras circunstancias excepcionales alineadas con estos criterios.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

Should you require any reasonable adjustments or arrangements to support you during the recruitment process, specific to your individual needs, please contact us on esp-inclusion.recruitment@gsk.com.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov